Rhodium-Catalyzed Regioselective C7-Olefination of Indazoles Using an N-Amide Directing Group

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• 作者：Lei Guo ; Yanyu Chen ; Rong Zhang ; Qiujun Peng ; Dr. Lanting Xu and Prof. Dr. Xianhua Pan
• 刊名：Chemistry – An Asian Journal
• 出版年：2017
• 出版时间：February 1, 2017
• 年：2017
• 卷：12
• 期：3
• 页码：289-292
• 全文大小：865K
• ISSN：1861-471X

文摘

A rhodium-catalyzed regioselective C−H olefination of indazole is described. This protocol relies on the use of an efficient and removable N,N-diisopropylcarbamoyl directing group, which offers facile access to C7-olefinated indazoles with high regioselectivity, ample substrate scope and broad functional group tolerance.