Chemoenzymatic Synthesis of -Cyano Epoxides by a Tandem-Knoevenagel-Epoxidation Reaction
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- 作者：Fengjuan Yang ; Xiaowen Zhang ; Fengxi Li ; Zhi Wang and Lei Wang
- 关键词：Domino reactions ; Enzyme catalysis ; Nucleophilic addition ; Epoxidation
- 刊名：European Journal of Organic Chemistry
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：2016
- 期：7
- 页码：1251-1254
- 全文大小：853K
- ISSN：1099-0690
文摘
An efficient lipase-mediated synthesis of -cyano epoxides through a tandem-Knoevenagel–epoxidation reaction was explored for the first time. This method provides a green, mild, and convenient route for the synthesis of -cyano epoxides; moreover, the applicability of lipase in organic synthesis is further extended.