A General Chemoenzymatic Strategy for the Synthesis of Glycosphingolipids
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- 作者：Yunpeng Liu ; Liuqing Wen ; Lei Li ; Madhusudhan Reddy Gadi ; Wanyi Guan ; Kenneth Huang ; Zhongying Xiao ; Mohui Wei ; Cheng Ma ; Qing Zhang ; Hai Yu ; Xi Chen ; Peng George Wang and Junqiang Fang
- 刊名：European Journal of Organic Chemistry
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：2016
- 期：25
- 页码：4315-4320
- 全文大小：1181K
- ISSN：1099-0690
文摘
A concise, prototypical, and stereoselective strategy for the synthesis of therapeutically and immunologically significant glycosphingolipids has been developed. This strategy provides a universal platform for glycosphingolipid synthesis by block coupling of enzymatically prepared free oligosaccharideglycans to lipids using glycosyl N-phenyltrifluoroacetimidates as efficient activated intermediates. As demonstrated here, two different types of glycosphingolipids were obtained in excellent yields using the method.