Antihyperglycemic and antioxidant activity of water extract from Anoectochilus roxburghii in experimental diabetes
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- 作者：Shi-Chao Cui ; Jie Yu ; cshch009@gmail.com ; cshch_009@163.com ; Xiao-Hui Zhang ; Mei-Zhen Cheng ; La-Wei Yang ; Jing-Yan Xu
- 关键词：Anoectochilus roxburghii ; Hypoglycemic ; Antioxidant ; Alloxan-induced diabetic mice ; Water extract
- 刊名：Experimental and Toxicologic Pathology
- 出版年：2013
- 出版时间：July, 2013
- 年：2013
- 卷：65
- 期：5
- 页码：485-488
- 全文大小：268 K
文摘
The hypoglycemic and antioxidant effects of the water extract from Anoectochilus roxburghii in alloxan-induced diabetic mice were examined. Compared with untreated diabetic mice, the daily oral administration of the water extract from A. roxburghii at 0.5 or 2 g/kg for 14 days caused a significant decrease (p < .05) in blood glucose levels with similar effect but no evidence of dose-related effect. Simultaneously, the alteration in lipid metabolism was partially attenuated as evidenced by decreased serum total cholesterol and triglyceride levels and by increased high-density lipoprotein cholesterol concentration in diabetic mice (p < .05) but no dose-related effect was observed. In addition, the water extract from A. roxburghii caused a significant increase (p < .05) in the activities of enzymic antioxidants and the levels of vitamin E in liver and kidney of diabetic mice.
Our results suggest that water extract from A. roxburghii possesses hypoglycemic and antioxidant properties after oral administration to mice showing alloxan-induced diabetes.