Back to the future: Immunization with M-001 prior to trivalent influenza vaccine in 2011/12 enhanced protective immune responses against 2014/15 epidemic strain

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• 作者：George H. Lowell ; Sagit Ziv ; Svetlana Bruzil ; Ron Babecoff ; Tamar Ben-Yedidia ; ^{benyedidia@biondvax.com}
• 关键词：Influenza ; Vaccine ; Universal ; CMI ; HAI ; Multimeric-001 ; M-001 ; Clinical trial
• 刊名：Vaccine
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：35
• 期：5
• 页码：713-715
• 全文大小：234 K
• 卷排序：35

文摘

There is an urgent need for a better flu vaccine with broad specificity. M-001 vaccine is based on conserved influenza peptides. M-001 can be used as a primer that enhances HAI response to TIV in human. Sera of elderly immunized with M-001 and TIV contained HAI Ab to future epidemic strain. M-001 influenza vaccine can broaden protective immunity and improve the health of elderly.