Differential characterization using readily accessible NMR experiments of novel N- and O-alkylated quinolin-4-ol, 1,5-naphthyridin-4-ol and quinazolin-4-ol derivatives with antimycobacterial activity
Azaheterocyclic analogues of quinoloxyacetamide antimycobacterials are reported. Potent antimycobacterial scaffolds were identified. Unambiguous structure determination was carried out by 13C-NMR, HSQC/HMBC and NOE. NMR methodology can be applied generally for ambident heterocyclic nucleophiles.