Cigarette smoke extracts induce overexpression of the proto-oncogenic gene interleukin-13 receptor α2 through activation of the PKA-CREB signaling pathway to trigger malignant transformation of lung vascular endothelial cells and angiogenesis

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• 作者：Mei Meng¹ ; Huaidong Liao¹ ; Bin Zhang¹ ; Yanyan Pan ; Ying Kong ; Wenming Liu ; Ping Yang ; Zihe Huo ; Zhifei Cao ; Quansheng Zhou ; ^{zhouqs@suda.edu.cn}
• 关键词：Lung cancer ; Cigarette smoke extract ; Angiogenesis ; Tumor-associated endothelial cells ; IL-13Rα2 ; CT-19
• 刊名：Cellular Signalling
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：31
• 期：Complete
• 页码：15-25
• 全文大小：1834 K
• 卷排序：31

文摘

Cigarette smoke extracts induce overexpression of pro-tumorigenic IL-13Rα2 gene. CSEs induce IL-13Rα2 overexpression by activation of the PKA-CREB signaling axis. IL-13Rα triggers malignant transformation of ECs and promotes tumor angiogenesis.