Interleukin-4 receptor signaling and its binding mechanism: A therapeutic insight from inhibitors tool box

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• 作者：Zaheer Ul-Haq^a ; ^{zaheer.qasmi@iccs.edu}Author Vitae ; Sehrish Naz^a ; M. Ahmed Mesaik^a ; ^b
• 关键词：Interleukin-4 ; Allergic asthma ; Cancers ; Antagonistic antibodies ; Immunotoxins ; IL-4 mutant analogs
• 刊名：Cytokine & Growth Factor Reviews
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：32
• 期：Complete
• 页码：3-15
• 全文大小：2136 K
• 卷排序：32

文摘

Interleukin-4 is the prime anti-inflammatory cytokine involved in cell proliferation, gene expression and apoptosis. α chain of IL-4R is also a fundamental part of IL-13R hence, signifying its role in both IL-4 and IL-13 signaling pathway. IL-4/IL-4Rα interface persists a charge complementarity which develop polar contacts between crucial residues of both. Enhance expression of IL-4/IL-4Rα plays significant role in progression of allergic, malignant, and viral diseases. Various IL-4/IL-4Rα modulators have been designed but all of these exhibit several pharmacological problems.