Grass carp (Ctenopharyngodon idella) ATF6 (activating transcription factor 6) modulates the transcriptional level of GRP78 and GRP94 in CIK cells
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- 作者：Xiangqin Wanga ; Tao Zhanga ; Huiling Maoa ; huilinm6@163.com" class="auth_mail" title="E-mail the corresponding author ; Yichuan Mia ; Bin Zhonga ; Lili Weib ; Xiancheng Liua ; Chengyu Hua ; hucy2008@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ATF6 ; Endoplasmic reticulum stress ; Unfolded protein respond ; GRP78 and GRP94 ; Transcriptional control
- 刊名：Fish & Shellfish Immunology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：52
- 期：Complete
- 页码：65-73
- 全文大小：3011 K
文摘
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The full-length cDNA of grass carp ATF6 was cloned and identified.
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CiATF6 was significantly up-regulated after stimulation with thermal stress.
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In vitro, CiATF6 had high affinity with CiGRP78 and CiGRP94 promoters.
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CiATF6 played a positive role in CiGRP78 and GRP94 transcription in CIK cells.
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