Fluorometric and molecular docking investigation on the binding characteristics of SB202190 to human serum albumin
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- 作者：Ahmad N. Nasruddina ; Shevin R. Feroza ; Abdul K. Mukarramb ; Saharuddin B. Mohamadb ; c ; Saad Tayyaba ; c ; saadtayyab2004@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：SB202190 ; Human serum albumin ; Drug&ndash ; protein interaction ; Fluorescence spectroscopy ; Molecular docking
- 刊名：Journal of Luminescence
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：174
- 期：Complete
- 页码：77-84
- 全文大小：3540 K
文摘
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SB202190 interacts with HSA with moderate affinity.
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Involvement of hydrophobic and van der Waals forces in SB202190 binding.
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SB202190 binding results in microenvironmental changes around fluorophores.
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Sudlow׳s site I is the preferred binding site of SB202190.