1, 25(OH)₂D₃-induced interaction of vitamin D receptor with p50 subunit of NF-κB suppresses the interaction between KLF5 and p50, contributing to inhibition of LPS-induced macrophage proliferation

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• 作者：Dong Ma^a ; ^b ; Ruo-nan Zhang^a ; Ya Wen^c ; Wei-na Yin^d ; Disi Bai^b ; Guo-ying Zheng^b ; Jin-shui Li^a ; Bin Zheng^a ; Jin-kun Wen^a ; ^{wjk@hebmu.edu.cn}
• 关键词：1 ; 25(OH)2D3 ; Vitamin D receptor ; NF-κB ; KLF5 ; Macrophage ; Proliferation
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：8 January 2017
• 年：2017
• 卷：482
• 期：2
• 页码：366-374
• 全文大小：1852 K
• 卷排序：482

文摘

1, 25(OH)2D3 suppresses LPS-induced KLF5 expression via upregulation of VDR expression. KLF5 interacts with NF-κB-p50 to cooperatively induce the expressions of positive cell cycle regulators cyclin B1 and Cdk1/Cdc2 in LPS-treated macrophages. 1,25(OH)2D3 induces interaction of VDR with p50.