Magic angle spinning ³¹P NMR spectroscopy reveals two essentially identical ionization states for the cardiolipin phosphates in phospholipid liposomes

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• 作者：E.E. Kooijman^a ; ^{ekooijma@kent.edu} ; L.A. Swim^a ; ¹ ; Z.T. Graber^b ; ² ; Y.Y Tyurina^c ; H. Bayır^d ; V.E. Kagan^c
• 关键词：Mitochondria ; Membrane electrostatics ; Cardiolipin-protein interactions ; Electron transport ; Lipid ionization ; Membrane structure
• 刊名：Biochimica et Biophysica Acta (BBA) - Biomembranes
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1859
• 期：1
• 页码：61-68
• 全文大小：734 K
• 卷排序：1859

文摘

31P NMR reveals essentially one, very low, pKa value for both phosphates of Cardiolipin. At low pH Cardiolipin has significantly reduced chemical stability as compared to other phospholipids. At low pH Cardiolipin alone, and in mixtures with PC forms the hexagonal (HII) phase.