TNF-¦Á polymorphisms and coronary artery disease: Association study in the Korean population

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• 作者：Ho-Chan Cho^a ; Gyeongim Yu^b ; Mi-Young Lee^b ; Hye-Soon Kim^a ; Dong-Hoon Shin^b ; ^{ho3632@kmu.ac.kr} ; Yoon-Nyun Kim^a ; ^{ho3632@freechal.com}
• 关键词：CAD ; coronary artery disease ; TNF-¦Á ; tumor necrosis factor-¦Á
• 刊名：Cytokine
• 出版年：2013
• 出版时间：April, 2013
• 年：2013
• 卷：62
• 期：1
• 页码：104-109
• 全文大小：265 K

文摘

Coronary artery disease (CAD) results from atherosclerosis, a chronic inflammatory disease mediated in part by proinflammatory cytokines, particularly tumor necrosis factor-¦Á (TNF-¦Á), which is expressed by atherosclerotic plaques. In this study, we investigated whether TNF-¦Á gene promoter polymorphisms affect the incidence of CAD in Koreans by genotyping. 404 Control subjects and 197 patients who previously received a coronary artery stent for the G/A, C/T, and C/A polymorphisms at position ?238, ?857 and ?863, respectively. The G/G, G/A and A/A genotypes at position ?238 occurred in 85.8 % , 14.2 % and 0 % CAD patients and 91.8 % , 7.9 % and 0.3 % control subjects, respectively. The G/A polymorphisms at position ?238 were significantly associated with CAD when assuming a dominant model of inheritance (OR = 1.87; 95 % CI = 1.10-3.20; P = 0.02), and A allele carriers had a significantly increased risk of developing CAD relative to the G allele (OR = 1.74; 95 % CI = 1.04-2.92; P = 0.03). However, the polymorphisms at positions ?857 and ?863 were not associated with CAD. Haplotype-based analysis revealed the CAD and control groups differed significantly in the frequencies of haplotype ACC at positions ?238, ?857 and ?863 (OR = 1.77; 95 % CI = 1.05-2.98; P = 0.03). This was confirmed by multivariate analysis after adjusting body mass index and the presence of diabetes and hypertension (OR = 2.06; 95 % CI = 1.15-3.68; P = 0.015). Thus, the ?238A allele of TNF-¦Á is associated with an increased risk of CAD and could be used as predictor for CAD in Koreans. Further studies are needed to elucidate the clinical implications of these findings.