The RNA helicase DDX39B and its paralog DDX39A regulate androgen receptor splice variant AR-V7 generation

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• 作者：Daisuke Nakata^a ; Shoichi Nakao^b ; ^c ; Kazuhide Nakayama^a ; Shinsuke Araki^a ; ^b ; Yusuke Nakayama^b ; ^c ; Samuel Aparicio^b ; ^d ; ^e ; Takahito Hara^a ; ^{takahito.hara@takeda.com} ; Atsushi Nakanishi^b ; ^c ; ^{atsushi.nakanishi@takeda.com}
• 关键词：AR-V7 ; DDX39B ; UAP56 ; DDX39A ; URH49 ; Castration-resistant prostate cancer
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：271-276
• 全文大小：1529 K
• 卷排序：483

文摘

Dysregulation of RNA processing pathway was suggested to underlie AR-V7 expression. An shRNA screen identified DDX39B as a factor contributing to AR-V7 generation. Simultaneous silencing of DDX39B and its paralog DDX39A nearly abolished AR-V7.