Targeted disruption of the orphan receptor Gpr151 does not alter pain-related behaviour despite a strong induction in dorsal root ganglion expression in a model of neuropathic pain

详细信息    查看全文

• 作者：Fiona E. Holmes^a ; ^c ; Niall Kerr^a ; ^c ; Ying-Ju Chen^a ; ^c ; Penny Vanderplank^a ; ^c ; Craig A. McArdle^b ; David Wynick^a ; ^c ; ^{d.wynick@bristol.ac.uk}
• 关键词：Gpr151 ; Galanin ; GalR1 ; GalR2 ; Dorsal root ganglion ; Pain
• 刊名：Molecular and Cellular Neuroscience
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：78
• 期：Complete
• 页码：35-40
• 全文大小：360 K
• 卷排序：78

文摘

Gpr151 is an orphan GPCR of unknown function. RT-PCR demonstrated a 50-fold increase in Gpr151 mRNA in the DRG 7 days after a nerve injury model of neuropathic pain. Acute, inflammatory and neuropathic pain behaviours were unchanged between Gpr151 mutant mice and wild-type controls. Galanin did not induce calcium signalling responses in ND7/23 cells transfected with Gpr151.