Surface proteome analysis identifies platelet derived growth factor receptor-alpha as a critical mediator of transforming growth factor-beta-induced collagen secretion
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- 作者：Katharina Heinzelmanna ; Nina Noskovičová ; a ; Juliane Merl-Phamb ; Gerhard Preisslerc ; Hauke Winterc ; Michael Lindnerd ; Rudolf Hatzc ; d ; Stefanie M. Hauckb ; Jü ; rgen Behrd ; e ; Oliver Eickelberga ; oliver.eickelberg@helmholtz-muenchen.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：ECM ; Extracellular matrix ; IPA ; Ingenuity pathway analysis ; IPF ; Idiopathic pulmonary fibrosis ; PDGFRα ; Platelet-derived growth factor receptor-alpha ; PDGFRβ ; Platelet-derived growth factor receptor-beta ; phF ; Primary human fibroblasts ; αSMA ; alpha-Smooth muscle actin ; TGF-β ; Transforming growth factor-beta
- 刊名：International Journal of Biochemistry and Cell Biology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：74
- 期：Complete
- 页码：44-59
- 全文大小：3639 K
文摘
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TGF-β significantly regulates 213 proteins of the human fibroblast surface proteome.
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PDGFRα expression and the number of positive cells is down-regulated by TGF-β.
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TGF-β induces PDGF signaling by phosphorylation of Akt dependent on PDGFR expression.
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Decreased PDGFRα levels correlate with increased expression of PDGFRβ, αSMA and collagen type V.