Comparison of liposomal and NLC (nanostructured lipid carrier) formulations for improving the transdermal delivery of oxaprozin: Effect of cyclodextrin complexation

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• 作者：N. Mennini ; M. Cirri ; F. Maestrelli ; P. Mura ; ^{paola.mura@unifi.it}
• 关键词：Oxaprozin (PubChem CID 4614) ; Randomly-methylated-ß ; -cyclodextrin (PubChem CID 122143) ; l-Arginine (PubChem CID 6322) ; Sodium cholate (PubChem CID 23668194) ; Polyoxyethylene sorbitan monoleate (PubChem CID 86289060) ; Stearylamine (PubChem CID 15793) ; Caprylocaproyl macrogol-8 glycerides (Labrasol® ; ) ; Glycerol distearate (Precirol® ; ATO 5) ; Carbopol 940 (PubChem CID 6581 ; Acrylic Acid)
• 刊名：International Journal of Pharmaceutics
• 出版年：2016
• 出版时间：30 December 2016
• 年：2016
• 卷：515
• 期：1-2
• 页码：684-691
• 全文大小：655 K
• 卷排序：515

文摘

Development and comparison of liposomal and NLC (nanostructured lipid carrier) formulations to improve topical bioavailability of oxaprozin. Evaluation of the effectiveness of the combined approach of drug cyclodextrin (CD) complexation and complex entrapment in nanocarriers (NC). Permeation studies by artificial membranes: better power of drug-CD-NC systems than drug-NC or drug-CD ones; higher effect of liposomes than NLC. Permeation studies by human skin confirmed such results and evidenced an enhancer effect of NC components and/or of randomly-methylated ßCD.