A novel H6N1 virus-like particle vaccine induces long-lasting cross-clade antibody immunity against human and avian H6N1 viruses
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- 作者：Ji-Rong Yanga ; b ; c ; Chih-Yuan Chenb ; Chuan-Yi Kuob ; Chieh-Yu Chengb ; Min-Shiuh Leed ; Ming-Chu Chengd ; Yu-Chih Yangc ; Chia-Ying Wuc ; Ho-Sheng Wub ; e ; Ming-Tsan Liub ; mtliu@cdc.gov.tw" class="auth_mail" title="E-mail the corresponding author ; Pei-Wen Hsiaoa ; c ; pwhsiao@gate.sinica.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Influenza A (H6N1) virus ; Virus-like particle vaccine ; Broad-spectrum protective immunity
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：126
- 期：Complete
- 页码：8-17
- 全文大小：2300 K
文摘
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This study characterizes the first H6N1 vaccine against human and avian influenza viruses.
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H6N1-VLP vaccine induced antibodies that neutralized viruses in vivo and in vitro.
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H6N1-VLP antibodies neutralized conserved epitopes in the HA head and stem domains.
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VLP antibodies neutralized hemagglutination and replication in cross-clade viruses.