Ro 90-7501 inhibits PP5 through a novel, TPR-dependent mechanism

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• 作者：Tae-Joon Hong^a ; Kwanghyun Park^a ; Eun-Wook Choi^b ; Ji-Sook Hahn^a ; ^{hahnjs@snu.ac.kr}
• 关键词：Protein phosphatase 5 (PP5) ; Ro 90-7501 ; Inhibitor screening ; TPR-dependent inhibition
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：8 January 2017
• 年：2017
• 卷：482
• 期：2
• 页码：215-220
• 全文大小：672 K
• 卷排序：482

文摘

Ro 90-7501, aurothioglucose, N-oleoyldopamine were identified as PP5 inhibitors. Ro 90-7501 required the TPR domain of PP5 to inhibit PP5 efficiently. The TPR-dependent PP5 inhibition of Ro 90-7501 demonstrates a novel mechanism.