Tyrosine hydroxylase haploinsufficiency prevents age-associated arterial pressure elevation and increases half-life in mice

详细信息    查看全文

• 作者：Luis Gamella-Pozuelo^a ; ^b ; ^c ; Marí ; a T Grande^a ; Milagros Clemente-Lorenzo^d ; Cayetana Murillo-Gó ; mez^c ; ^e ; Flora De Pablo^c ; ^e ; José ; M Ló ; pez-Novoa^a ; ^b ; Catalina Hern&aacute ; ndez-S&aacute ; nchez^c ; ^e ; ^{chernandez@cib.csic.es}
• 关键词：Catecholamines ; Tyrosine hydroxylase ; Hypertension ; Stress ; Life-span
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1863
• 期：1
• 页码：113-120
• 全文大小：710 K
• 卷排序：1863

文摘

A lack of age-associated AP increase found in mature adult Th-hetrozygous mice. The Th-hetrozygous mice had an increased half-life. The catecholaminergic response to stress was diminished in the Th-hetrozygous group.