Virgin olive oil enriched with its own phenolic compounds or complemented with thyme improves endothelial function: The potential role of plasmatic fat-soluble vitamins. A double blind, randomized, controlled, cross-over clinical trial

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• 作者：Rosa-M. Valls^a ; ¹ ; Marta Farrà ; s^b ; ^c ; ¹ ; Anna Pedret^a ; ¹ ; Sara Fern&aacute ; ndez-Castillejo^a ; Ú ; rsula Catal&aacute ; n^a ; Marta Romeu^e ; Montse Giralt^e ; Guillermo-T. S&aacute ; ez^f ; Montserrat Fitó ; ^b ; Rafael de la Torre^g ; Marí ; a-Isabel Covas^b ; Marí ; a-José ; Motilva^d ; ^{motilva@tecal.udl.es} ; Rosa Solà ; ^a ; ^{rosa.sola@urv.cat} ; Laura Rubió ; ^a ; ^d
• 关键词：FVOO ; functional virgin olive oil ; GPx ; glutathione peroxidase ; HPLC ; high performance liquid chromatography ; hsCRP ; high sensitivity C-reactive protein ; ICAM-1 ; intercellular cell adhesion molecule ; ICH GPC ; international conference of harmonization ; IRH ; ischemic reactive hyperemia ; MCP-1 ; monocyte chemotactic protein ; NOx ; nitric oxide ; PAI-1 ; plasminogen activator inhibitor type I ; PC ; phenolic compounds ; TG ; triglycerides ; UPLC-MS/MS ; ultra performance liquid chromatography-mass spectrometr
• 刊名：Journal of Functional Foods
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：28
• 期：Complete
• 页码：285-292
• 全文大小：730 K
• 卷排序：28

文摘

The aim of the present study was to assess whether different functional virgin olive oils (FVOOs) with varying phenolic compounds (PC) could protect the plasmatic fat-soluble vitamins, which in turn could improve the endothelial function. In order to select the optimal phenolic dose in the improvement of ischemic reactive hyperemia (IRH), a dose-response study (n = 12, healthy subjects) was performed and the enrichment of 500 mg PC/kg oil was selected. In a 3-week cross-over sustained study (n = 33 hypercholesterolemic subjects), the consumption of 25 mL/day of two phenol-enriched olive oils (one enriched with its own PC and another combined with thyme PC) increased IRH and plasma concentrations of retinol, β-cryptoxanthin and α-tocopherol, compared to a control virgin olive oil. A positive post-intervention correlation was observed for IRH values and HDL-c, β-cryptoxanthin, lutein and α-tocopherol. Results suggest that preservation of plasmatic fat-soluble vitamins by PC from FVOOS could partially explain the endothelial function benefits.