Guarana (Paullinia cupana) ameliorates memory impairment and modulates acetylcholinesterase activity in Poloxamer-407-induced hyperlipidemia in rat brain

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• 作者：Jader B. Ruchel^a ; ^{jbruchel@yahoo.com.br} ; Josiane B.S. Braun^a ; Stephen A. Adefegha^a ; Alessandra Guedes Manzoni^a ; F&aacute ; tima H. Abdalla^a ; Juliana S. de Oliveira^a ; Kelly Trelles^a ; Cristiane Signor^a ; Sô ; nia T. A Lopes^b ; C&aacute ; ssia B. da Silva^b ; Lí ; via G. Castilhos^c ; Maribel A. Rubin^a ; Daniela B. R Leal^a ; ^{dbitencourtrosaleal@gmail.com}
• 关键词：Caffeine ; Hyperlipidemia ; Memory ; Paullinia cupana ; Simvastatin
• 刊名：Physiology & Behavior
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：168
• 期：Complete
• 页码：11-19
• 全文大小：710 K
• 卷排序：168

文摘

Guaraná reduced total cholesterol and LDL-C in hyperlipidemic rats. Guarana prevents memory impairment induced by hyperlipidemia. Anxiety-like behaviors is not altered either by hyperlipidemia or by guarana, caffeine or simvastatin. Guarana prevented the alterations induced by hyperlipidemia in AChE activity in the hippocampus. Guarana could be used as adjuvant therapy in hyperlipidemic patients.