Multicystic dysplastic kidney: Assessment of the need for renal scintigraphy and the safety of conservative treatment

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• 作者：M.E. Carazo-Palacios^a ; ^{hellencarazo@gmail.com} ; M. Couselo-Jerez^a ; A. Serrano-Durb&aacute ; ^b ; B. Pemartí ; n-Comella^a ; C. Sangü ; esa-Nebot^c ; F. Estornell-Moragues^b ; C. Domí ; nguez-Hinarejos^b
• 关键词：Multicystic kidney ; Nephroblastoma ; Renal scintigraphy
• 刊名：Actas Urológicas Españolas (English Edition)
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：41
• 期：1
• 页码：62-67
• 全文大小：528 K
• 卷排序：41

文摘

To assess the need for implementing renal scintigraphy in the diagnosis of the multicystic dysplastic kidney (MCDK) and the safety of its conservative treatment.Material and methodsA retrospective study of patients with unilateral MCDK was conducted at our center from January 2005 to August 2015. We calculated the positive predictive value (PPV) of ultrasonography, taking renal scintigraphy and pathology as the gold standard. We calculated a survival curve according to the Kaplan–Meier method to assess the annual probability of spontaneous resolution of the multicystic kidney.ResultsFifty-six patients were identified, 48 (85.7%) of whom had a prenatal diagnosis. Thirty eight (67.9%) of the patients were males, and the left side was affected in 33 (58.9%) of the patients. We observed associated urological abnormalities in 22 (39.29%) patients, with vesicoureteral reflux the most common (8, 14.29%). Seven patients (12.5%) developed renal failure. Forty-nine (87.5%) patients developed compensatory contralateral renal hypertrophy. Of the 33 patients who underwent surgery, the pathology results confirmed the MCDK diagnosis in 32. Compared with scintigraphy and pathology, the PPV of ultrasonography was 100% and 97%, respectively.The rate of spontaneous involution was 5.4% at 3 months of life, 11.3% at 2 years and 38.4% at 5 years.ConclusionsIn our experience, the conservative treatment of MCDK, until at least 5 years of age, is safe. Our data suggest that performing scintigraphy is not required for these patients, which means lower radiation exposure, as well as financial savings.