Synthesis of carotenoid-monosaccharide conjugates via azide-alkyne click-reaction

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• 作者：Attila Agó ; cs^a ; É ; va Bokor^b ; Anikó ; Tak&aacute ; tsy^a ; Tam&aacute ; s Ló ; r&aacute ; nd^a ; Jó ; zsef Deli^a ; ^c ; L&aacute ; szló ; Soms&aacute ; k^b ; Veronika Nagy^a ; ^{vera.nagy@aok.pte.hu}
• 关键词：Amphipathic ; Carotenoid pentynoates ; Glycosides ; Click reaction ; Unprotected sugar
• 刊名：Tetrahedron
• 出版年：2017
• 出版时间：2 February 2017
• 年：2017
• 卷：73
• 期：5
• 页码：519-526
• 全文大小：493 K
• 卷排序：73

文摘

Carotenoid pentynoates were coupled to protected and unprotected sugar azides via an azide-alkyne click-reaction using bis-triphenylphosphano-copper(I)-butyrate (C3H7COOCu(PPh3)2) complex. Protected sugars delivered the conjugates with excellent yields, whereas with unprotected ones amphipathic carotenoid-sugar derivatives were obtained in good or moderate yields in a simple way.