Simultaneous determination of atorvastatin and valsartan in human plasma by solid-based disperser liquid-liquid microextraction followed by high-performance liquid chromatography-diode array detection
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- 作者：Mir Ali Farajzadeha ; mafarajzadeh@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; mafarajzadeh@tabrizu.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Parisa Khorrama ; Azar Pazhohanb
- 关键词：AALLME ; air-assisted liquid&ndash ; liquid microextraction ; DLLME ; dispersive liquid&ndash ; liquid microextraction ; HPLC ; high performance liquid chromatography ; LOD ; limit of detection ; LOQ ; limit of quantification ; LPME ; liquid phase microextraction ; RSD ; relative standard deviation ; SDME ; single drop microextraction ; SPE ; solid phase extraction ; SPME ; solid phase microextraction
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：1017-1018
- 期：Complete
- 页码：62-69
- 全文大小：1891 K
文摘
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A liquid–liquid microextraction by solid disperser followed by HPLC–DAD was presented.
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Two cardiovascular drugs in human plasma are analyzed simultaneously.
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Application of sugar cube as a safe disperser is a notable exclusivity of the method.
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Small amounts of both biological sample and organic solvent are needed in this method.