Regulation of the adrenoleukodystrophy-related gene (ABCD2): Focus on oxysterols and LXR antagonists
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- 作者：Doriane Trompier ; Catherine Gondcaille ; Gé ; rard Lizard ; Sté ; phane Savary ; stsavary@u-bourgogne.fr" class="auth_mail
- 关键词：LXR antagonists ; Oxysterols ; Adrenoleukodystrophy ; Peroxisome ; ABC transporters ; Neurodegenerative disorders
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：11 April 2014
- 年：2014
- 卷：446
- 期：3
- 页码：651-655
- 全文大小：418 K
文摘
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Induction of ABCD2 is recognized as a therapeutic strategy for X-ALD.
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The known inducers of ABCD2 and regulatory pathways are described.
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LXR antagonists are novel inducers of ABCD2.
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A few LXR antagonists that have been described are presented.
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Their potential use for neurodegenerative disorders is discussed.