Chronic restraint stress causes a delayed increase in responding for palatable food cues during forced abstinence via a dopamine D₁-like receptor-mediated mechanism

详细信息    查看全文

• 作者：Kevin T. Ball ; ^{kball@bloomu.edu} ; Olivia Best ; Jonathan Luo ; Leah R. Miller
• 关键词：CS ; conditioned stimulus ; D1R ; D1-like receptor ; HPA ; hypothalamic-pituitary-adrenal ; PTSD ; post-traumatic stress disorder ; FR ; fixed ratio ; PFC ; prefrontal cortex
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：319
• 期：Complete
• 页码：1-8
• 全文大小：1475 K
• 卷排序：319

文摘

Relapse to unhealthy eating habits in dieters is often triggered by acute stress. The role of chronic stress in relapse vulnerability, however, is less clear. We assessed the role of chronic stress in relapse to palatable food seeking in rats. Chronically stressed rats displayed increased food seeking 7 days after stress. Blockade of D1-like receptors during chronic stress reversed this effect.