Chronic FAAH inhibition during nicotine abstinence alters habenular CB1 receptor activity and precipitates depressive-like behaviors

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• 作者：A. Simonnet^a ; ^b ; E. Zamberletti^c ; M. Cador^a ; ^b ; T. Rubino^c ; S. Caillé ; ^a ; ^b ; ^{stephanie.garnier@u-bordeaux.fr}
• 关键词：Nicotine ; Abstinence ; Depressive-like behavior ; CB1 receptor ; Habenula ; Rat
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：252-259
• 全文大小：674 K
• 卷排序：113

文摘

Nicotine dependent rats show anhedonia upon nicotine cessation. We investigated the effects of URB597, a FAAH inhibitor, on depressive symptoms during abstinence. Chronic FAAH inhibition induces depressive-like behaviors in nicotine abstinent rats. CB1 receptor activity in the habenula is decreased only in FAAH treated nicotine rats.