Inactivated porcine reproductive and respiratory syndrome virus vaccine adjuvanted with Montanide™ Gel 01 ST elicits virus-specific cross-protective inter-genotypic response in piglets
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- 作者：Kairat Tabynova ; tabynov777@mail.ru" class="auth_mail" title="E-mail the corresponding author ; tabynov777@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Abylay Sansyzbaya ; Zhanara Tulemissovab ; Kaissar Tabynova ; Santosh Dhakalc ; Aigul Samoltyrovaa ; Gourapura J. Renukaradhyac ; Muratbay Mambetaliyeva
- 关键词：PRRSV ; Killed vaccines ; Binary ethylenimine ; Neutralizing antibodies ; Polymeric adjuvant ; Cross-protection
- 刊名：Veterinary Microbiology
- 出版年：2016
- 出版时间：30 August 2016
- 年：2016
- 卷：192
- 期：Complete
- 页码：81-89
- 全文大小：2177 K
文摘
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BEI-inactivated PRRSV candidate vaccine was developed using local Kazakh viral strains.
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Immune response and clinical disease were compared with a commercial PRRSV vaccine.
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Compared to commercial vaccine our vaccine induced better cross-protective response.
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Use of a potent adjuvant and local PRRSV strains in the vaccine formulation is beneficial.