Using porous CaCO₃/hyaluronic acid nanocages to accommodate hydrophobic photosensitizer in aqueous media for photodynamic therapy

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• 作者：Qianqian Dong^a ; ^b ; Jieling Li^b ; Lingyun Cui^b ; Honglei Jian^b ; Anhe Wang^b ; ^{ahwang@ipe.ac.cn} ; ^{wangah@nanoctr.cn} ; Shuo Bai^b ; ^{baishuo@ipe.ac.cn}
• 关键词：CaCO3 nanoparticles ; Hyaluronic acid ; Photosensitizer ; Photodynamic therapy
• 刊名：Colloids and Surfaces A: Physicochemical and Engineering Aspects
• 出版年：2017
• 出版时间：5 March 2017
• 年：2017
• 卷：516
• 期：Complete
• 页码：190-198
• 全文大小：3697 K
• 卷排序：516

文摘

Porous CaCO3 nanoparticles with a size about 250 nm and high stability in aqueous solution have been synthesized in one pot for PDT. Hydrophobic photosensitizer hypocrellin B (HB) could be encapsulated by the CaCO3 nanoparticles to enhance the solubility and stability. The CaCO3 nanoparticles loading with HB can be further modified by targeting molecule hyaluronic acid to improve the stability of nano-carrier.