On the trail of the glycan codes stored in cancer-related cell adhesion proteins

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• 作者：Dorota Hoja-Łukowicz^a ; ^{dorota.hoja-lukowicz@uj.edu.pl} ; Małgorzata Przybyło^a ; ^{malgorzata.przybylo@uj.edu.pl} ; Małgorzata Duda^b ; ^{maja.duda@uj.edu.pl} ; Ewa Pocheć^a ; ^{ewa.pochec@uj.edu.pl} ; Monika Bubka^a ; ^{monika.bubka@uj.edu.pl}
• 关键词：Lea ; Galβ1-3(Fucα1-4)GlcNAcβ ; Leb ; Fucα1-2Galβ1-4(Fucα1-3)GlcNAcβ ; Lex ; Galβ1-4(Fucα1-3)GlcNAcβ ; Ley ; Fucα1-2Galβ1-3(Fucα1-4)GlcNAcβ
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1861
• 期：1
• 页码：3237-3257
• 全文大小：4494 K
• 卷排序：1861

文摘

Changed glycosylation of CAMs is essential for their maturation, translocation to the cell surface and function. Altered E-cadherin glycosylation influences the early step of neoplastic transformation. Altered N-cadherin glycosylation influences neoplastic cells migration and invasion. Altered integrins and Ig-CAMs glycosylations influence each step of the metastatic cascade.