Deletion of histone deacetylase 3 in adult beta cells improves glucose tolerance via increased insulin secretion

详细信息    查看全文

• 作者：Jarrett R. Remsberg¹ ; ² ; ³ ; Benjamin N. Ediger¹ ; ² ; Wesley Y. Ho¹ ; ² ; Manashree Damle¹ ; ² ; Zhenghui Li¹ ; ² ; Christopher Teng² ; Cristina Lanzillotta¹ ; ² ; Doris A. Stoffers¹ ; ² ; Mitchell A. Lazar¹ ; ² ; ^{lazar@mail.med.upenn.edu}
• 关键词：HDAC3 ; Glucose tolerance ; Insulin secretion
• 刊名：Molecular Metabolism
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：6
• 期：1
• 页码：30-37
• 全文大小：1510 K
• 卷排序：6

文摘

HDAC3 ablation in adult mouse β-cells improves glucose tolerance. Improved glucose tolerance is due to increased insulin secretion. HDAC3 targets multiple genes involved in potentiating insulin secretion.