Label-free detection of acetylcholinesterase and its inhibitor based on the in situ formation of fluorescent copper nanoparticles

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• 作者：Pengjuan Ni^a ; ^bAuthor Vitae ; Yujing Sun^aAuthor Vitae ; Shu Jiang^a ; ^bAuthor Vitae ; Wangdong Lu^a ; ^bAuthor Vitae ; Yilin Wang^a ; ^bAuthor Vitae ; Zhen Li^a ; ^bAuthor Vitae ; Zhuang Li^a ; ^{zli@ciac.ac.cn}Author Vitae
• 关键词：Copper nanoparticles ; Poly(thymine) ; Label-free ; Fluorescence detection ; Acetylcholinesterase
• 刊名：Sensors and Actuators B: Chemical
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：240
• 期：Complete
• 页码：651-656
• 全文大小：1260 K
• 卷排序：240

文摘

A novel fluorescent assay for AChE and its inhibitor detection has been developed. This novel assay is based on the fluorescent copper nanoparticles. This assay shows high sensitivity and selectivity for AChE activity detection.