FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

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• 作者：Rudolf Zechner¹ ; ^{rudolf.zechner@uni-graz.at} ; Robert Zimmermann¹ ; Thomas  ; O. Eichmann¹ ; Sepp  ; D. Kohlwein¹ ; Guenter Haemmerle¹ ; Achim Lass¹ ; Frank Madeo¹
• 刊名：Cell Metabolism
• 出版年：2012
• 出版时间：7 March, 2012
• 年：2012
• 卷：15
• 期：3
• 页码：279-291
• 全文大小：671 K

文摘

Lipolysis is defined as the catabolism of triacylglycerols stored in cellular lipid droplets. Recent discoveries of essential lipolytic enzymes and characterization of numerous regulatory proteins and mechanisms have fundamentally changed our perception of lipolysis and its impact on cellular metabolism. New findings that lipolytic products and intermediates participate in cellular signaling processes and that ¡°lipolytic signaling?is particularly important in many nonadipose tissues unveil a previously underappreciated aspect of lipolysis, which may be relevant for human disease.