Retinyl ester hydrolases and their roles in vitamin A homeostasis

详细信息    查看全文

• 作者：Renate  ; Schreiber^a ; Ulrike  ; Taschler^a ; Karina  ; Preiss-Landl^a ; Nuttaporn  ; Wongsiriroj^a ; Robert  ; Zimmermann^a ; Achim  ; Lass ;   ; ^a ;   ; ^{achim.lass@uni-graz.at}
• 关键词：Vitamin A ; Retinyl ester hydrolase ; Lipid droplet ; Mobilization ; Neutral lipid ; Store
• 刊名：Biochimica et Biophysica Acta (BBA)/Molecular and Cell Biology of Lipids
• 出版年：2012
• 出版时间：January 2012
• 年：2012
• 卷：1821
• 期：1
• 页码：113-123
• 全文大小：413 K

文摘

In mammals, dietary vitamin A intake is essential for the maintenance of adequate retinoid (vitamin A and metabolites) supply of tissues and organs. Retinoids are taken up from animal or plant sources and subsequently stored in form of hydrophobic, biologically inactive retinyl esters (REs). Accessibility of these REs in the intestine, the circulation, and their mobilization from intracellular lipid droplets depends on the hydrolytic action of RE hydrolases (REHs). In particular, the mobilization of hepatic RE stores requires REHs to maintain steady plasma retinol levels thereby assuring constant vitamin A supply in times of food deprivation or inadequate vitamin A intake. In this review, we focus on the roles of extracellular and intracellular REHs in vitamin A metabolism. Furthermore, we will discuss the tissue-specific function of REHs and highlight major gaps in the understanding of RE catabolism. This article is part of a Special Issue entitled Retinoid and Lipid Metabolism.