A novel simplified synthesis of acivicin

详细信息    查看全文

• 作者：Andrea Pinto ; Paola Conti ; Lucia Tamborini ; Carlo De Micheli
• 刊名：Tetrahedron: Asymmetry
• 出版年：2009
• 出版时间：11 March 2009
• 年：2009
• 卷：20
• 期：4
• 页码：508-511
• 全文大小：315 K

文摘

This report describes an efficient synthesis of the natural isomer of acivicin, which is the only one provided with a noteworthy biological activity. The present procedure allowed the synthesis of (+)-1 in just five steps with a 34 % overall yield. Due to the easy separation of the two diastereomers and to the availability of the starting material at low cost, the present procedure can be scaled-up to gram quantities.