Expression of pro-inflammatory genes in human endothelial cells: Comparison of rivaroxaban and dabigatran
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- 作者：Peter Ellinghausa ; peter.ellinghaus@bayer.com" class="auth_mail" title="E-mail the corresponding author ; Elisabeth Perzbornb ; elisabeth.perzborn@bayer.com" class="auth_mail" title="E-mail the corresponding author ; Peter Hauenschilda ; peter.hauenschild@bayer.com" class="auth_mail" title="E-mail the corresponding author ; Christoph Gerdesc ; christoph.gerdes@bayer.com" class="auth_mail" title="E-mail the corresponding author ; Stefan Heitmeierc ; stefan.heitmeier@bayer.com" class="auth_mail" title="E-mail the corresponding author ; Mayken Visserc ; mayken.visser@bayer.com" class="auth_mail" title="E-mail the corresponding author ; Holger Summerd ; holger.summer@bayer.com" class="auth_mail" title="E-mail the corresponding author ; Volker Lauxc ; volker.laux@bayer.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACTB ; cytosolic β-actin ; APC ; activated protein C ; B2M ; β-2-microglobulin ; CXCL ; chemokine (C-X-C motif) ligand ; MCP ; chemokine (C-C motif) ligand ; DMSO ; dimethyl sulfoxide ; ELAM ; endothelial leukocyte adhesion molecule ; EBM ; endothelial cell basal medium ; HUVEC ; human umbilical vein endothelial cell ; ICAM ; intercellular adhesion molecule ; IL ; interleukin ; MMP ; matrix metalloproteinase ; ANOVA ; one-way analysis of variance ; PC ; protein C ; PAR ; proteinase-activated receptor ; RFI ; relative fluoresc
- 刊名：Thrombosis Research
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：142
- 期：Complete
- 页码：44-51
- 全文大小：1330 K
文摘
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Thrombin-induced PAR-1 activation mediates inflammatory gene expression in HUVECs.
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Rivaroxaban and dabigatran downregulated the expression of pro-inflammatory markers.
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Low concentrations of dabigatran (3–300 nM) increased inflammatory gene expression.
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Dabigatran at low concentrations showed a transient increase in thrombin activity.
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