Agreement of skin test with IL-4 production and CD40L expression by T cells upon immunotherapy of subjects with systemic reactions to Hymenoptera stings
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- 作者：José ; M. Urraa ; d ; jmurra@sescam.jccm.es" class="auth_mail" title="E-mail the corresponding author ; Carmen M. Cabrerab ; Teresa Alfayac ; Francisco Feo-Britoc ; d
- 关键词：VIT ; Hymenoptera venom immunotherapy ; BAT ; basophil activation test ; IDT ; intradermal test ; sIgE ; specific IgE antibodies
- 刊名：Molecular Immunology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：70
- 期：Complete
- 页码：134-139
- 全文大小：634 K
文摘
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Hymenoptera venom immunotherapy reduces the expression of CD40L and CTLA-4 on T CD4 lymphocytes.
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Hymenoptera venom immunotherapy decline the IL-4 producing T lymphocytes and increase IFN-γ producing T lymphocytes.
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The modifications induced by immunotherapy on IL-4 and CD40L link to those seen in skin test.
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Neither basophil activation test nor the sIgE levels, are not linked to the immune changes induced by immunotherapy.