Cucurbitacin B interacts synergistically with antibiotics against Staphylococcus aureus clinical isolates and exhibits antiviral activity against HSV-1

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• 作者：S.T.S. Hassan^a ; ^b ; ^{sherif.hassan@seznam.cz} ; K. Berchová ; -Bí ; mová ; ^b ; J. Petrá ; &scaron ; ^a ; K.T.S. Hassan^c
• 关键词：Ecballium elatrium ; Cucurbitacin B ; HSV ; Staphylococcus aureus ; Synergy
• 刊名：South African Journal of Botany
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：108
• 期：Complete
• 页码：90-94
• 全文大小：278 K
• 卷排序：108

文摘

Cucurbitacin B exerted direct growth-inhibitory activity against all S. aureus strains tested with MICs values ranging from 0.12 to 0.44 μg/mL. Cucurbitacin B interacts synergistically with antibiotics against S. aureus strains with (ƩFIC ranging from 0.29 to 0.43). Cucurbitacin B exerted anti-HSV-1 activity compared with that of acyclovir with IC50 values of 0.94 and 1.74 μM, respectively. Cucurbitacin B as a natural antimicrobial agent will play an important role in the development of anti-staphylococcal and antiherpetic drugs.