Distal M domain of cobra ADAM-like metalloproteinase mediates the binding of positively charged cysteine-rich domain to αvβ3 integrin in the suppression of cell migration
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- 作者：Po-Long Wua ; b ; 1 ; Chien-Chu Lina ; 1 ; Ting-Hui Lina ; c ; Min-Shi Leec ; Wen-Guey Wua ; lswwg@life.nthu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Snake venom metalloproteinases (SVMPs) ; Atragin ; Kaouthiagin-like ; Taiwan cobra venom ; Cell migration ; Integrin
- 刊名：Toxicon
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：118
- 期：Complete
- 页码：1-12
- 全文大小：2237 K
文摘
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Novel integrin binding mode is through distal sites in MDC domain of SVMP.
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The overall shapes of ADAM-like protein affect target selection.
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Cobra venom consists of non-RGD integrin binding toxins to perturb wound healing.