Iridoid-loganic acid versus anthocyanins from the Cornus mas fruits (cornelian cherry): Common and different effects on diet-induced atherosclerosis, PPARs expression and inflammation
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- 作者：Tomasz Sozańskia ; tsoz@wp.pl" class="auth_mail" title="E-mail the corresponding author ; Alicja Z. Kucharskab ; Andrzej Rapakc ; Dorota Szumnya ; Małgorzata Trochaa ; Anna Merwid-Ląda ; Stanisław Dzimirad ; Tomasz Piaseckie ; Narcyz Pió ; reckif ; g ; Jan Magdalana ; Adam Szeląga
- 关键词：Cornelian cherry ; Iridoids ; Anthocyanins ; Loganic acid ; Atherosclerosis ; Hypercholesterolemia ; PPARα ; PPARγ ; IL-6 ; TNFα
- 刊名：Atherosclerosis
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：254
- 期：Complete
- 页码：151-160
- 全文大小：1231 K
文摘
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Both iridoid loganic acid and a mixture of anthocyanins from Cornelian cherry fruits diminished dyslipidemia in rabbits.
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Anthocyanins and to a lesser extent loganic acid decreased intima thickness and intima/media ratio in the thoracic aorta.
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Anthocyanins significantly increased expression of PPARγ, both anthocyanins and loganic acid increased expression of PPARα.
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Loganic acid, though not anthocyanins, showed anti-inflammatory effects – decreasing TNFα and IL-6 activity.
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Our results indicate the potential health benefits of fruits containing both anthocyanins and iridoids.