Extracellular functions of 14-3-3 adaptor proteins

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• 作者：Andrew Kaplan ; ^{andrew.kaplan@mail.mcgill.ca} ; Mardja Bueno ; Alyson E. Fournier
• 关键词：APN ; CD13 ; MMP ; Stratifin ; Exosome ; Biomarker ; 14-3-3
• 刊名：Cellular Signalling
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：31
• 期：Complete
• 页码：26-30
• 全文大小：893 K
• 卷排序：31

文摘

14-3-3 adaptor proteins are released into the extracellular environment in exosomes. Altered levels of extracellular 14-3-3s are associated with disease states. 14-3-3s bind to aminopeptidase N (APN) and stimulate MMP activity and tissue remodeling. 14-3-3s may regulate the extracellular release of client proteins. Extracellular 14-3-3s can serve as biomarkers and drug targets.