Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways
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- 作者：Jessica Brandia ; Ilaria Dandob ; Elisa Dalla Pozzab ; Giulia Biondanib ; Rosalind Jenkinsc ; Victoria Elliottd ; Kevin Parkc ; Giuseppina Fanellie ; Lello Zollae ; Eithne Costellod ; Aldo Scarpaf ; Daniela Cecconia ; daniela.cecconi@univr.it" class="auth_mail" title="E-mail the corresponding author ; Marta Palmierib
- 关键词：Pancreatic cancer ; Cancer stem cells ; Pancreatic ductal adenocarcinoma PDAC
- 刊名：Journal of Proteomics
- 出版年：2017
- 出版时间：6 January 2017
- 年：2017
- 卷：150
- 期：Complete
- 页码：310-322
- 全文大小：1854 K
文摘
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iTRAQ proteomic analysis of pancreatic cancer stem cells (Panc1 CSCs)
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Identification of 230 differentially expressed proteins of Panc1 CSCs
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Activation of glycolysis, pentose phosphate pathway, pyruvate-malate cycle, and lipid metabolism
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Downregulation of Krebs cycle, spliceosome and non homologous end joining
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Fatty acids synthesis and mevalonate pathways directly involved in Panc1 CSCs viability