Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer

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• 作者：Christopher J. Halbrook¹ ; Costas A. Lyssiotis¹ ; ² ; ^{clyssiot@med.umich.edu}
• 关键词：pancreatic cancer ; PDAC ; tumor metabolism ; metabolic imaging ; metabolic reprogramming ; stroma ; Kras ; metabolic crosstalk ; HP-MRI ; FDG-PET
• 刊名：Cancer Cell
• 出版年：2017
• 出版时间：9 January 2017
• 年：2017
• 卷：31
• 期：1
• 页码：5-19
• 全文大小：1892 K
• 卷排序：31

文摘

Pancreatic ductal adenocarcinoma is on pace to become the second leading cause of cancer-related death. The high mortality rate results from a lack of methods for early detection and the inability to successfully treat patients once diagnosed. Pancreatic cancer cells have extensively reprogrammed metabolism, which is driven by oncogene-mediated cell-autonomous pathways, the unique physiology of the tumor microenvironment, and interactions with non-cancer cells. In this review, we discuss how recent efforts delineating rewired metabolic networks in pancreatic cancer have revealed new in-roads to develop detection and treatment strategies for this dreadful disease.