Ancestral benzo[a]pyrene exposure affects bone integrity in F3 adult fish (Oryzias latipes)

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• 作者：Frauke Seemann^a ; Chang-Bum Jeong^b ; Ge Zhang^c ; Miles Teng Wan^a ; Baosheng Guo^c ; Drew Ryan Peterson^a ; Jae-Seong Lee^b ; Doris Wai-Ting Au^a ; ^{bhdwtau@cityu.edu.hk}
• 关键词：AcvR1b ; activating receptor type 1b ; ALP ; alkaline phosphatase ; APC ; adenomatous polyposis coli ; ATF4 ; activating transcription factor 4 ; BaP ; benzo[a]pyrene ; BMD ; bone mineral density ; BMP2 ; bone morphogenetic protein 2 ; Col2a1b ; collagen 2a1b ; Col10 ; collagen 10a1 ; CTSK ; cathepsin K ; dph ; days post hatching ; miRNA ; microRNA ; OB ; Osteoblast ; OP ; Osteoprogenitor ; OPN ; osteopontin ; Osx ; osterix ; PTHrP ; para-thyroidhormone-receptor protein ; Rankl ; receptor activator of nuclear factor-κB ligand ; Ru
• 刊名：Aquatic Toxicology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：183
• 期：Complete
• 页码：127-134
• 全文大小：2306 K
• 卷排序：183

文摘

BaP-induced transgenerational bone impairment is not recoverable in adult F3 fish. Decreased bone thickness and increased number of microcracks were revealed. Five pairs of mRNA/miRNA might be involved in decreased osteoblast activity.