Effect of high glucose concentrations on human erythrocytes in vitro
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- 作者：Jana Viskupicovaa ; Dusan Blaskovica ; Sabina Galiniakb ; Mirosław Soszyńskic ; Grzegorz Bartoszb ; c ; Lubica Horakovaa ; Izabela Sadowska-Bartoszb ; isadowska@poczta.fm" class="auth_mail" title="E-mail the corresponding author
- 关键词：ATPase ; adenosinetriphosphatase ; BSA ; bovine serum albumin ; EDTA ; ethylenediaminetetraacetic acid ; EGTA ; ethylene glycol tetraacetic acid ; FITC ; fluorescein isothiocyanate ; GLUT1 ; glucose transporter 1 ; GR ; glutathione reductase ; GSH ; reduced glutathione ; GSSG ; oxidized glutathione ; GST ; glutathione S-transferase ; Hb ; hemoglobin ; HMF ; 5-(hydroxymethyl)-2-furaldehyde ; PBS ; phosphate-buffered saline ; PMCA ; plasma membrane Ca2+-ATPase ; PS ; phosphatidylserine ; RBCs ; red blood cells ; RQB ; redox quenc
- 刊名：Redox Biology
- 出版年：2015
- 出版时间：August 2015
- 年：2015
- 卷：5
- 期：Complete
- 页码：381-387
- 全文大小：811 K
文摘
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Erythrocytes were incubated for up to 72 h in 5 mM, 45 mM and 100 mM glucose.
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High glucose concentrations intensified lipid peroxidation.
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High glucose attenuated hemolysis, eryptosis, Ca2+ accumulation and glutathione loss.
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Glucose is a glycating agent but also energy source.
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Results of exposure to high glucose should be interpreted with care.