Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics
详细信息 查看全文
- 作者：Karthik Shekhar1 ; 9 ; Sylvain W. Lapan2 ; 7 ; 9 ; Irene E. Whitney4 ; 9 ; Nicholas M. Tran4 ; Evan Z. Macosko2 ; 5 ; 6 ; Monika Kowalczyk1 ; Xian Adiconis1 ; 5 ; Joshua Z. Levin1 ; 5 ; James Nemesh2 ; 5 ; 6 ; Melissa Goldman2 ; 5 ; Steven A. McCarroll2 ; 5 ; 6 ; Constance L. Cepko2 ; 3 ; 7 ; cepko@genetics.med.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Aviv Regev1 ; 7 ; 8 ; aregev@broadinstitute.org" class="auth_mail" title="E-mail the corresponding author ; Joshua R. Sanes4 ; 10 ; sanesj@mcb.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：25 August 2016
- 年：2016
- 卷：166
- 期：5
- 页码：1308-1323.e30
- 全文大小：22422 K
文摘
- •
Unsupervised clustering of 25,000 single-cell transcriptomes reveals 15 bipolar types
- •
Molecularly defined types correspond 1:1 to morphologically defined types
- •
One previously undescribed bipolar cell type has hybrid bipolar-amacrine features
- •
Shallow sequencing of large cell numbers facilitates comprehensive classification