Emerging Complexities in Adipocyte Origins and Identity

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• 作者：Joan Sanchez-Gurmaches¹ ; Chien-Min Hung¹ ; David A. Guertin¹ ; ^{david.guertin@umassmed.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：brown adipocyte ; brite adipocyte ; beige adipocyte ; white adipocyte ; UCP1 ; thermogenesis ; adipose tissue development ; obesity ; lipodystrophy
• 刊名：Trends in Cell Biology
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：26
• 期：5
• 页码：313-326
• 全文大小：2758 K

文摘

The global incidence of obesity and its comorbidities continues to rise along with a demand for novel therapeutic interventions. Brown adipose tissue (BAT) is attracting attention as a therapeutic target because of its presence in adult humans and high capacity to dissipate energy as heat, and thus burn excess calories, when stimulated. Another potential avenue for therapeutic intervention is to induce, within white adipose tissue (WAT), the formation of brown-like adipocytes called brite (brown-like-in-white) or beige adipocytes. However, understanding how to harness the potential of these thermogenic cells requires a deep understanding of their developmental origins and regulation. Recent cell-labeling and lineage-tracing experiments are beginning to shed light on this emerging area of adipocyte biology. We review here adipocyte development, giving particular attention to thermogenic adipocytes.