Fat body remodeling and homeostasis control in Drosophila

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• 作者：Huimei Zheng^a ; ^b ; ^c ; Xiaohang Yang^a ; ^b ; ^d ; Yongmei Xi^a ; ^b ; ^{xyyongm@zju.edu.cnc}
• 关键词：20E ; 20-hydroxyecdysone ; AKH ; Adipokinetic hormone ; AKHR ; Adipokinetic hormone receptor ; ALS ; Acid-labile subunit ; APF ; After pupariation formation ; ATGL ; Adipose triglyceride lipase ; Bmm ; Brummer ; CC ; Corpus cardiacum ; DILP ; Drosophila insulin-like polypeptide ; IGF ; Insulin/insulin like growth factor ; IGF-BPs ; Insulin-like growth factor binding proteins ; IIS ; Insulin/insulin like growth factor signaling ; Imp-L2 ; Imaginal morphogenesis protein-Late 2 ; IPCs ; Insulin-producing cells ; InR ; Insulin
• 刊名：Life Sciences
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：167
• 期：Complete
• 页码：22-31
• 全文大小：1129 K
• 卷排序：167

文摘

Remarkable advances have been made in recent years in our understanding of the Drosophila fat body and its functions in energy storage, immune response and nutrient sensing. The fat body interplays with other tissues to respond to the physiological needs of the body's growth and coordinates various metabolic processes at different developmental stages and under different environmental conditions. The identification of various conserved genetic functions and signaling pathways relating to the Drosophila fat body may provide clues to lipometabolic disease and other aspects of tissue remodeling in humans. Here, we discuss recent insights into how regulation of fat body remodeling contributes to hemostasis with a special focus on how signaling networks and internal physiological states shape different aspects of the lipid metabolism in Drosophila.