Immunohistochemical localization of alpha and beta adrenergic receptors in the human nasal turbinate

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• 作者：Hideaki Shirasaki ; ^{shira@sapmed.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Etsuko Kanaizumi ; Tetsuo Himi
• 关键词：Upper airway ; Alpha adrenergic receptor ; Beta adrenergic receptor ; Human turbinate ; Immunohistochemistry
• 刊名：Auris Nasus Larynx
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：43
• 期：3
• 页码：309-314
• 全文大小：2400 K

文摘

Adrenergic receptors (ARs) include four general types (α1, α2, β1 and β2), which are found in different target tissues. α-AR agonists are commonly used for decongestant therapy of upper airway diseases. In order to clarify the roles of AR subtypes in the upper airways, we investigated the localization of these receptors by immunohistochemistry.

2">Methods

Human turbinates were obtained after turbinectomy from 12 patients with nasal obstruction refractory to medical therapy. The specific cells expressing α- and β-AR proteins were identified by immunostaining using an anti-human AR subtype-specific antibodies (α1A-, α1D-, α2C- and β2-ARs) antibody.

Results

Immunohistochemical analysis revealed that immunoreactivities for α1D- and β2-ARs were densely distributed in submucosal glands. In contrast, immunoreactivities for α1A- and 2C-ARs were densely distributed in vascular smooth muscle.

Conclusion

20">Our results suggested that adrenergic receptor (AR) subtypes had different roles in upper airway diseases, such as allergic rhinitis and nonallergic rhinitis.